Shortening treatment of tuberculosis: lessons from fluoroquinolone trials.

نویسندگان

  • Camus Nimmo
  • Marc Lipman
  • Patrick P J Phillips
  • Timothy McHugh
  • Andrew Nunn
  • Ibrahim Abubakar
چکیده

www.thelancet.com/infection Vol 15 February 2015 141 4 Lipsitch M, Cohen T, Cooper B, et al. Transmission dynamics and control of severe acute respiratory syndrome. Science 2003; 300: 1966–70. 5 Fraser C, Donnelly CA, Cauchemez S, et al. Pandemic potential of a strain of infl uenza A (H1N1): early fi ndings. Science 2009; 324: 1557–61. 6 Lewnard JA, Ndeff o Mbah ML, Alfaro-Murillo JA, et al. Dynamics and control of Ebola virus transmission in Montserrado, Liberia: a mathematical modelling analysis. Lancet Infect Dis 2014; 14: 1189–95. 7 Pandey A, Atkins KE, Medlock J, et al. Strategies for containing Ebola in west Africa. Science 2014; 346: 991–95. 8 Chowell G, Nishiura H. Transmission dynamics and control of Ebola virus disease (EVD): a review. BMC Med 2014; 12: 196. 9 Merler S, Ajelli M, Fumanelli L, et al. Spatiotemporal spread of the 2014 outbreak of Ebola virus disease in Liberia and the eff ectiveness of nonpharmaceutical interventions: a computational modelling analysis. Lancet Infect Dis 2015; published online Jan 7. http://dx.doi.org/10.1016/ S1473-3099(14)71074-6 10 Chowell G, Viboud C, Hyman JM, Simonsen L. The western Africa Ebola virus disease epidemic exhibits both global exponential and local polynomial growth rates. PLoS Curr 2014; published online Nov 30. http://lanl.arxiv.org/abs/1411.7364. 11 Chowell G, Simonsen L, Viboud C, Kuang Y. Is West Africa approaching a catastrophic phase or is the 2014 Ebola epidemic slowing down? Diff erent models yield diff erent answers for Liberia. PLoS Curr 2014; published online Nov 20. DOI: 0.1371/currents.outbreaks.b4690859d91684da963dc40e00f3da81. 12 UN Offi ce for the Coordination of Humanitarian Aff airs. The humanitarian data exchange—Ebola treatment centers or units (ETCs or ETUs). 2014. https://data.hdx.rwlabs.org/dataset/ebola-treatment-centers (accessed Dec 14, 2014). microsimulations and other modelling approaches could prove instrumental to optimise interventions to curb and ultimately eliminate Ebola virus disease in the region, especially as an Ebola vaccine might materialise in the near future.

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BACKGROUND Fluoroquinolones are considered important substitutes for the treatment of tuberculosis. This study investigates the current status of fluoroquinolone for the treatment of tuberculosis. METHODS In 2009, a retrospective analysis was performed at one tertiary referral center for 953 patients diagnosed with tuberculosis. RESULTS A total of 226 patients (23.6%), who received fluoroqu...

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TUBERCULOSIS Empirical treatment with a fluoroquinolone delays the treatment for tuberculosis and is associated with a poor prognosis in endemic areas

Background: A study was conducted to evaluate the effect of the empirical use of fluoroquinolones on the timing of antituberculous treatment and the outcome of patients with tuberculosis in an endemic area. Methods: All patients with culture confirmed tuberculosis aged >14 years diagnosed between July 2002 and December 2003 were included and their medical records were reviewed. Results: Seventy...

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Novel drugs against tuberculosis: a clinician's perspective.

The United Nations Millennium Development Goal of reversing the global spread of tuberculosis by 2015 has been offset by the rampant re-emergence of drug-resistant tuberculosis, in particular fluoroquinolone-resistant multidrug-resistant and extensively drug-resistant tuberculosis. After decades of quiescence in the development of antituberculosis medications, bedaquiline and delamanid have bee...

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عنوان ژورنال:
  • The Lancet. Infectious diseases

دوره 15 2  شماره 

صفحات  -

تاریخ انتشار 2015